Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9
نویسندگان
چکیده
منابع مشابه
Regorafenib suppresses sinusoidal obstruction syndrome in rats.
BACKGROUND Sinusoidal obstruction syndrome (SOS), a form of drug-induced liver injury related to oxaliplatin treatment, is associated with postoperative morbidity after hepatectomy. This study aimed to examine the impact of regorafenib, the first small-molecule kinase inhibitor to show efficacy against metastatic colorectal cancer, on a rat model of SOS. METHODS Rats with monocrotaline (MCT)-...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2012
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2012.07.004